LMO1

Rhombotina 1
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	LMO1 (HGNC: 6641) MGC116692, RBTN1, RHOM1, TTG1
Identificadores; externos	OMIM: 186921 ; MGI: 102812 ; HomoloGene: 48101 ; EBI: LMO1; GeneCards: Gen LMO1; UniProt: LMO1;
Locus	Cr. 11 p15.4
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
4004	109594
Véase HS	Véase MM
P25800	Q924W9
NM_001270428	NM_057173
NP_001257357	NP_476514
Cr. 11:; 8.25 – 8.29 Mb	Cr. 7:; 109.14 – 109.17 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

Rhombotina 1 es una proteína codificada en humanos por el gen LMO1.^[1]^[2]^[3]

El gen LMO1 codifica un factor de transcripción rico en cisteínas y con dos dominios LIM. Se localiza en una región del cromosoma 11 susceptible de sufrir traslocaciones. De hecho, es una gen que aparece mutado y eliminado en algunos tipos de leucemia de linfocitos T, aunque más raramente que otro gen de la misma familia, LMO2, mucho más común en este tipo de leucemias.^[3]

Interacciones

La proteína LMO1 ha demostrado ser capaz de interaccionar con:

GATA3^[4]^[5]
TAL1^[6]^[7]

Referencias

↑ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (Jun de 1991). «The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13». Proc Natl Acad Sci U S A 88 (10): 4367-71. PMC 51660. PMID 2034676.
↑ McGuire EA, Davis AR, Korsmeyer SJ (Mar de 1991). «T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells». Blood 77 (3): 599-606. PMID 1703797.
↑ ^a ^b «Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)».
↑ Ono, Y; Fukuhara N; Yoshie O (Dec. de 1998). «TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3». Mol. Cell. Biol. (UNITED STATES) 18 (12): 6939-50. ISSN 0270-7306. PMID 9819382.
↑ Ono, Y; Fukuhara N; Yoshie O (Feb. de 1997). «Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL». J. Biol. Chem. (UNITED STATES) 272 (7): 4576-81. ISSN 0021-9258. PMID 9020185.
↑ Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. de 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617-21. ISSN 0027-8424. PMID 8078932.
↑ Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. de 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20): 4831-9. ISSN 0261-4189. PMID 7957052.

Datos: Q18028607

[pmid2034676-1] Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (Jun de 1991). «The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13». Proc Natl Acad Sci U S A 88 (10): 4367-71. PMC 51660. PMID 2034676.

[pmid1703797-2] McGuire EA, Davis AR, Korsmeyer SJ (Mar de 1991). «T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells». Blood 77 (3): 599-606. PMID 1703797.

[entrez-3] «Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)».

[pmid9819382-4] Ono, Y; Fukuhara N; Yoshie O (Dec. de 1998). «TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3». Mol. Cell. Biol. (UNITED STATES) 18 (12): 6939-50. ISSN 0270-7306. PMID 9819382.

[pmid9020185-5] Ono, Y; Fukuhara N; Yoshie O (Feb. de 1997). «Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL». J. Biol. Chem. (UNITED STATES) 272 (7): 4576-81. ISSN 0021-9258. PMID 9020185.

[pmid8078932-6] Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. de 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617-21. ISSN 0027-8424. PMID 8078932.

[pmid7957052-7] Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. de 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20): 4831-9. ISSN 0261-4189. PMID 7957052.

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